PhenoSense®, offered as a single HIV drug resistance test and in the combination test PhenoSense® GT, represents cutting-edge resistance testing technology. PhenoSense provides a direct, quantitative measurement of how well a patient's virus responds to antivirals. PhenoSense drug resistance results are provided with a measure of viral fitness or replication capacity.
PhenoSense drug resistance results are provided with a measure of viral fitness represented by replication capacity.
PhenoSense utilizes advanced molecular biology and cellular virology techniques to determine a rapid and precise measure of susceptibility to antiretroviral drugs. The capacity to perform these techniques in a reliable and robust, high-throughput manner is a core strength of Monogram Biosciences.
1. Isolating the viral RNA
2. Constructing the test vector
3. Producing and testing the virus
4. Measuring resistance
†Fold change: A ratio of the drug concentration needed to inhibit the patient’s virus relative to that of a wild-type control strain.