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PhenoSense®, offered as a single HIV drug resistance test and in the combination test PhenoSense® GT, represents cutting-edge resistance testing technology. PhenoSense provides a direct, quantitative measurement of how well a patient's virus responds to antivirals. PhenoSense drug resistance results are provided with a measure of viral fitness or replication capacity.
The PhenoSense report form includes drug resistance information for all of the approved nucleoside reverse transcriptase inhibitors (NRTIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs).
PhenoSense utilizes advanced molecular biology and cellular virology techniques to determine a rapid and precise measure of susceptibility to antiretroviral drugs. The capacity to perform these techniques in a reliable and robust, high-throughput manner is a core strength of Monogram Biosciences.
1. Isolating the viral RNA
2. Constructing the test vector
3. Producing and testing the virus
4. Measuring resistance
†Fold change: A ratio of the drug concentration needed to inhibit the patient’s virus relative to that of a wild-type control strain.