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Trofile® is a phenotypic viral RNA assay that is the only commercially available tropism assay that has been clinically validated through use in Phase 2 and Phase 3 clinical studies to identify CCR5 antagonist candidates.1-3 One such drug, maraviroc, is available for clinical use. Trofile is a clinically validated assay for the selection of clinically appropriate patients for maraviroc.
Trofile has been shown to be accurate, precise, sensitive, reproducible, and robust in the measurement of HIV-1 co-receptor tropism. More than 23,000 samples have been tested using this assay.