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The HCV NS5A Drug Resistance Assay is a genotypic (sequencing) resistance assay that analyzes the nonstructural (NS) 5A region of hepatitis C virus (HCV) genotypes 1a or 1b using next-generation sequencing (NGS) techniques. Amino acid substitutions in the NS5A region are identified, and a viral susceptibility call for the direct-acting agents (DAAs) that inhibit the NS5A proteins is reported as either “resistance possible” or “none/undetermined”. Monogram offers NS5A testing for both HCV genotype 1 and HCV genotype 3 viruses.