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The Trofile® DNA Coreceptor Tropism Assay applies the proven performance of Trofile® to cell-associated viral DNA. For patients with undetectable viral loads, Trofile DNA can be considered when a patient’s viral tropism is unknown and substitution with a CCR5 antagonist is desired.
Unlike the standard Trofile assay, which uses viral RNA found in the plasma of patients with viral loads ≥1000 copies/mL, Trofile DNA uses viral DNA extracted from cells in a whole blood draw. Once we have this viral information, Trofile DNA runs on the same clinically validated platform as Trofile.