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GenoSure Archive® is the newest suppression management offering by Monogram Biosciences. GenoSure Archive is designed to provide HIV-1 antiretroviral (ARV) drug resistance data when standard resistance testing cannot be performed due to inadequate plasma viral load. The assay interrogates the viral archive using next-generation sequencing (NGS) methods to provide a list of the archived mutations and then assigns susceptibility calls of "sensitive", "resistant", or "resistance possible" based on those mutations.
GenoSure Archive provides valuable information for nucleoside reverse transcriptase inhibitors (NRTIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs), integrase inhibitors (INIs) and protease inhibitors (PIs) when considering regimen switches in virologically suppressed patients due to: